MUCOSAMIN® RECTAL GEL
Mucosamin® Rectal Gel is an adjuvant in the healing process of the rectal mucosa, and as treatment in the painful symptomatology of rectal mucositis caused by radiotherapy and/or chemotherapy of pelvic tumours.2
Mucosamin® Rectal Gel
Mucosamin® Rectal Gel treatment of rectal mucositis improves mucosa tropism, and is designed to prevent the onset of rectal mucositis and also avoid recurrence.2
Radiotherapy initially causes mucosal changes characterised by inflammation or cell death, but subsequently persistent cytokine activation in the submucosa leads to chronic effects such as progressive ischaemia, fibrosis and loss of stem cells. These ischaemic and fibrotic changes potentially cause chronic impairment of GI physiological functions.4
Acute changes in GI physiology can occur in any part of the GI tract that is exposed to radiotherapy, leading to clinical or subclinical symptoms.5
Acute radiation proctitis appears oedematous, beefy red, and may have ulceration or sloughing. Microscopically, there is a loss or distortion of the microvillus architecture with hyperaemia, oedema and ulceration.1
Acute radiation proctitis is caused by the death of rectal mucosal cells, and is confined to the lower 25cm of the large intestine.6
The degree of damage to the mucosa, submucosa and GI stem cells may play a role in the development of chronic problems. In addition, chemotherapy increases the sensitivity of non-cancerous tissues to damage from radiotherapy.4
In 2013, Macmillan Cancer Support estimated that 90,000 people in the UK were living with chronic changes in lower GI function following treatment of pelvic cancers.8
What is Mucosamin®
Mucosamin® Rectal Gel is a CE marked medical device that acts as protective layer when applied topically to the rectal mucosa.2
Mucosamin® Rectal Gel is indicated in the treatment of rectal mucositis caused by radiation treatment for cancer of the pelvic area, and is also indicated in rectal mucositis caused by chemotherapy, or combined treatments of chemotherapy and radiotherapy.2
Mucosamin® Rectal Gel is composed of micro-enemas based on hyaluronic acid; the main component of connective tissue, and is also composed of four amino acids to promote collagen formation.2
Mucosamin® Rectal Gel is an adjuvant in the healing process of the rectal mucosa, and as treatment in the painful symptomatology of rectal mucositis caused by radiotherapy and/or chemotherapy of pelvic tumours.
Mucosamin® Rectal Gel treatment of rectal mucositis improves mucosa trophism, and is designed to prevent the onset of rectal mucositis and also avoid recurrence.2
How does Mucosamin®
Rectal Gel help?
Rectal Gel help?
Mucosamin® Rectal Gel can be used to help preserve the mucosa trophism in order to prevent the onset of rectal mucositis.2